Lung cancer. Early evidence suggests that there is no relationship between levels of vitamin B12 in the blood and the risk of lung cancer. Martin, R. M. Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol. If you have any signs of bleeding, such as bleeding from your gums, nosebleeds, unusual bruising, or dark stools, contact your doctor right away.
Benito-Leon J, Porta-Etessam J. Shaky-leg syndrome and vitamin B12 deficiency. Ohta T, Ando K, Iwata T, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin vitamin B12. Tricor to lower my triglyceride level for almost six years. About 2 years ago, I found that I had knee pain and felt very weak in my knee. Without help, I could not stand up after sitting on the floor. I did not think that it was caused by Tricor. About a year ago, I started searching internet for possible causes of knee pain, and found that somebody had similar problems. He said that the pain disappeared after stopping to take Tricor. So I asked my doctor about it. Although he did not believe that Tricor could cause knee problem, he allowed me to stop taking Tricor for 3 months. Since then, I have never taken Tricor, and my knee pain was reduced gradually with time. Now, I can have normal activities without any problem. My knee is still weak when I walk up stairs, but I could not do it two years ago. Thus, I strongly believe that Tricor can cause knee problems in some patients.
Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Our Tricor Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. articles.
Herbert V, Jacob E, Wong KT, et al. Low serum vitamin B12 levels in patients receiving ascorbic acid in megadoses: studies concerning the effect of ascorbate on radioisotope vitamin B12 assay. Am J Clin Nutr. Tricor fenofibrate is an antilipemic agent and fibric acid prescribed for reducing "bad" and for example, and and for raising "good" cholesterol in the blood. Dillner, J. Smoking, diet, pregnancy and oral contraceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection.
Wierzbicki AS, Lumb PJ, Cheung J, Crook MA. Fenofibrate plus simvastatin therapy versus simvastatin plus cholestyramine therapy for familial hypercholesterolaemia. Goldin BR, Lichtenstein AH, Gorbach SL. Nutritional and metabolic roles of intestinal flora. In: Shils ME, Olson JA, Shike M, eds. Ahmad S. Gemfibrozil interaction with warfarin sodium coumadin. Bostom A, Shemin D, Gohh R, et al. Treatment of mild hyperhomocysteinemia in renal transplant recipients versus hemodialysis patients. Werbach MR. Nutritional strategies for treating chronic fatigue syndrome. Mevacor lovastatin US prescribing information. You healthcare professionals may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Gonzalez, C. A. The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence. Int. Beaulieu AJ, Gohh RY, Han H, et al. Enhanced reduction of fasting total homocysteine levels with supraphysiological versus standard multivitamin dose folic acid supplementation in renal transplant recipients. Zipursky, A. A randomized control trial of vitamin E therapy in the prevention of anemia in low birth weight LBW infants. Pediatr.
This medication is not recommended for use during pregnancy. It may harm an unborn baby. Discuss the risks and benefits with your doctor. Continued What Are Normal and High Levels? Kanai T, Takagi T, Masuhiro K, et al. Serum vitamin K level and bone mineral density in post-menopausal women. This drug may rarely cause muscle problems which can rarely lead to very serious conditions called and autoimmune myopathy. This drug may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Rocco A, Compare D, Coccoli P, et al. Vitamin B12 supplementation improves rates of sustained vital response in patients chronically infected with hepatitis C virus. Selhub, J. A prospective study on folate, B12, and pyridoxal 5'-phosphate B6 and breast cancer. Cancer Epidemiol. Berg, H. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Don't take larger amounts. The safety of larger amounts is unknown. Post-surgical stent placement: Avoid using a combination of vitamin B12, folate, and vitamin B6 after receiving a coronary stent. This combination may increase the risk of blood vessel narrowing. Allergy or sensitivity to cobalt or cobalamin: Do not use vitamin B12 if you have this condition. Leber's disease, a hereditary eye disease: Do not take vitamin B12 if you have this disease. It can seriously harm the optic nerve, which might lead to blindness. Abnormal red blood cells megaloblastic anemia: Megaloblastic anemia is sometimes corrected by treatment with vitamin B12. However, this can have very serious side effects. Don't attempt vitamin B12 therapy without close supervision by your healthcare provider. High numbers of red blood cells polycythemia vera: The treatment of vitamin B12 deficiency can unmask the symptoms of polycythemia vera. Fractures. Taking vitamin B12 and folic acid, with or without vitamin B6 daily for 2-3 years does not seem to reduce the risk of fractures in older people with osteoporosis.
Haglund, O. Effects of fish oil on risk factors for cardiovascular disease. Minireview based on a doctoral thesis. Ups. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Salom IL, Silvis SE, Doscherholmen A. Effect of cimetidine on the absorption of vitamin B12. Lonn E, Yusuf S, Dzavik V, et al. Effects of ramipril and vitamin E on atherosclerosis: the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E SECURE. Geraci MJ, McCoy SL, Aquino ME. Women with red urine: Hydroxocobalamin-induced chromaturia.
If you also take certain other drugs to lower your bile acid-binding resins such as or take this product at least 1 hour before or at least 4 hours after taking these medications. These products can react with this medication, preventing its full absorption. Holven KB, Holm T, Aukrust P, et al. Effect of folic acid treatment on endothelium-dependent vasodilation and nitric oxide-derived end products in hyperhomocysteinemic subjects. Thal, L. J. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. If you are also taking certain other drugs to lower your cholesterol bile acid-binding resins such as cholestyramine or colestipol take fenofibrate at least 1 hour before or at least 4 to 6 hours after taking these medications. These medications can bind to fenofibrate, preventing your body from fully absorbing the drug. Keep all away from children and pets. HDL cholesterol in diabetic patients treated with rosiglitazone and fibrate. This medication may rarely cause and problems. Salonen, J. T. Association between depressive symptoms and serum concentrations of homocysteine in men: a population study. If your doctor prescribes these medicines together, you may need to have your bleeding times checked more often. You may need an adjustment in the dose of your anticoagulant blood-thinner medicine. Patterson, A. A critical evaluation of the relationship between serum vitamin B, folate and total homocysteine with cognitive impairment in the elderly. What happens if I miss a dose? Patients who take Trilipix with a statin must either have coronary or a coronary heart disease risk equivalent and who are on optimal statin therapy to achieve their goal, according to the FDA.
Nenseter, M. S. Plasma homocysteine concentration related to diet, endothelial function and mononuclear cell gene expression among male hyperlipidaemic smokers. Eur. Salvadori, M. Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipients. Morita M, Yin G, Yoshimitsu S, et al. Folate-related nutrients, genetic polymorphisms, and colorectal cancer risk: The Fukuoka Colorectal Cancer Study. Robinson K, Arheart K, Refsum H, et al. Low circulating folate and vitamin B6 concentrations: Risk factors for stroke, peripheral vascular disease, and coronary artery disease. Christen WG, Glynn RJ, Chew EY, et al. Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women. The results were biased against TriCor, he says, because 17% of those in the placebo group were taking a statin vs. only 8% of those in the TriCor group. Diniz, A. Treatment for iron deficiency anaemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh. Eur. Yamada K, Shimodaira M, Chida S, et al. Degradation of vitamin B12 in dietary supplements. Int J Vitam Nutr Res.
What happens if I overdose? Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. Fenster, A. Measurement of carotid plaque and effect of vitamin therapy for total homocysteine. Clin. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Pravachol pravastatin sodium US prescribing information. Bristol-Myers Squibb Company July, 2016. Duthie SJ, Whalley LJ, Collins AR, et al. Homocysteine, B vitamin status, and cognitive function in the elderly. Smith AD. Homocysteine, B vitamins, and cognitive deficit in the elderly.
This drug may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit beverages. Elia M. Oral or parenteral therapy for B12 deficiency. Aldridge MA, Ito MK. Fenofibrate and warfarin interaction. Bockxmeer, F. M. Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life. Neurobiol. Taneja S, Strand TA, Kumar T, et al. Folic acid and vitamin B-12 supplementation and common infections in 6-30-mo-old children in India: a randomized placebo-controlled trial. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. SC once daily for 6-7 days. Then the dose may be given on alternate days for 7 doses followed by every 3-4 days for around 3 weeks. Knowler, W. C. Homocysteine and vitamin B12 concentrations and mortality rates in type 2 diabetes. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Kalofoutis, A. Correlation of folate, vitamin B12 and homocysteine plasma levels with depression in an elderly Greek population. Fishman SM, Christian P, West KP. The role of vitamins in the prevention and control of anaemia.
Mooij PN, Thomas CM, Doesburg WH, Eskes TK. Multivitamin supplementation in oral contraceptive users. Callaghan TS, Hadden DR, Tomkin GH. Megaloblastic anemia due to vitamin B12 malabsorption associated with longterm metformin treatment. Bonaa KH, Njolstad I, Ueland PM, et al. NORVIT: Homocysteine lowering and cardiovascular events after acute myocardial infarction. Fenofibrate may also be used for purposes not listed in this medication guide. Crowley, J. M. Folate and amine metabolites in senile dementia: a combined trial and biochemical study. Psychol. It is important to continue taking this medication even if you feel well. Most people with or do not feel sick. It may take up to 4 weeks before you get the full benefit of this drug. Assendelft, W. J. Subnormal vitamin B12 concentrations and anaemia in older people: a systematic review. BMC. What are the possible side effects of fenofibrate? Lussier-Cacan, S. Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in health. Stucker M, Pieck C, Stoerb C, et al. Topical vitamin B12 - a new therapeutic approach in atopic dermatitis - evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial. Tiemeier H, van Tuijl HR, Hofman A, et al. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Gharakhanian S, Navarette MS, Cardon B, Rozenbaum W. Vitamin B12 injections in patients treated with zidovudine. For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Do not share this medication with others. Andres E, Goichot B, Schlienger JL. Food cobalamin malabsorption: a usual cause of vitamin B12 deficiency. Arnolda, L. F. The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis. BMC. India. 1. The effects of supplemental oral iron administration to pregnant women. Schiffman, M. A nested case-control study of dietary factors and the risk of incident cytological abnormalities of the cervix. HDL-C reduction during rosiglitazone and fibrate treatment. Tyrer LB. Nutrition and the pill. On almost every other score, people on Tricor fared better, he says. Termanini B, Gibril F, Sutliff VE, et al. Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome. Stabler SP, Allen RH, Fried LP, et al. Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women. Trilipix. LDL levels dropped for all patients, but improvement in HDL and was greater for patients taking statins and Trilipix. Eastham RD. Warfarin dosage influenced by clofibrate plus age.
Ose, L. Effect of Norwegian fish powder on risk factors for coronary heart disease among hypercholesterolemic individuals. Nutr Metab Cardiovasc. Scott, J. M. Plasma homocysteine response to folate intervention in young women. Palva IP, Salokannel SJ, Palva HLA, et al. Drug-induced malabsorption of vitamin B12. VII Malabsorption of B12 during treatment with potassium citrate. For cyanide poisoning: Hydroxocobalamin Cyanokit has been given intravenously by IV for a total dose of up to 10 grams. The levels are checked after an overnight fast. Fat from a recent meal can muddy the picture. If you also take cholestyramine, colesevelam, colestipol: these other medicines should be taken at least 1 hour after or 4 hours before you take fenofibrate. Hausmann, S. Increased serum level of total homocysteine in CAPD patients despite fish oil therapy. Perit. Westlake, A. J. Effects of iron and folic acid antenatal supplements on maternal haematology and fetal wellbeing. Med. The dosage is based on your medical condition, response to treatment, and other you may be taking.
Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Malouf, R. and Grimley, Evans J. Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane. Karyadi, D. Weekly micronutrient supplementation to build iron stores in female Indonesian adolescents. If these rare effects occur, talk to your doctor. Clarke R, Armitage J. Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements. Jacobs, I. C. Review article: management of cyanide poisoning. Emerg. Freeman AG. Cyanocobalamin - a case for withdrawal: discussion paper. J Royal Soc Med. Nielsen, F. H. Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women. Galan, P. Evidence for a protective synergistic? Ellis FR, Nasser S. A pilot study of vitamin B12 in the treatment of tiredness. Trijbels, J. M. Effect of various regimens of vitamin B6 and folic acid on mild hyperhomocysteinaemia in vascular patients. J Inherit. Richards, S. Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia. J Intern. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. FDA pregnancy category C. It is not known whether fenofibrate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Hinselmann, M. Riboflavin status and anaemia in pregnant women.
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Rao, P. L. Pyriform sinus fistula. Satoh, K. Homocysteine as a predictive factor for hip fracture in stroke patients. Therapeutic Research Faculty 2009. Nyunt, K. K. A prophylactic trial of iron and folic acid supplements in pregnant Burmese women. Isr. Vitamin B12 is injected into the body for pernicious anemia, to prevent and treat vitamin B12 deficiency, and to prevent and treat a nervous system disorder called myelopathy, which can occur in people who are vitamin B12 deficient. It is also used for tremors, to treat Imerslund-Grasbeck disease, cyanide poisoning, nerve damage caused by shingles, diabetic nerve damage, tiredness or fatigue, chronic fatigue syndrome, hepatitis C, a condition in which the body products too much thyroid hormone, bleeding, cancer, psoriasis, and liver and kidney disease. It is also injected in the body to prevent arteries from re-clogging after surgery. How does it work?
Ireland JH, Eggert CH, Arendt CJ, Williams AW. Rhabdomyolysis with cardiac involvement and acute renal failure in a patient taking rosuvastatin and fenofibrate. Russell RM, Baik H, Kehayias JJ. Older men and women efficiently absorb vitamin B-12 from milk and fortified bread. Vollset, S. E. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl.
Nygard, O. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. Older adults may be more sensitive to the side effects of this drug, especially and change in the amount of urine problems. Nallamothu BK, Fendrick M, Rubenfire M, et al. Potential clinical and economic effects of homocysteine lowering. Godfrey PS, Toone BK, Carney MW, et al. Enhancement of recovery from psychiatric illness by methylfolate.
Dierkes J, Domrose U, Bosselmann P, et al. Homocysteine lowering effect of different multivitamin preparations in patients with end-stage renal disease. Have your checked regularly while taking this medication. Learn how to monitor your own pressure at home, and share the results with your doctor. Okuda, K. Discovery of vitamin B12 in the liver and its absorption factor in the stomach: a historical review. Anthony Keech, MD, an associate professor of medicine at the University of Sydney in Australia.